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Furthermore, Lys802 made a hydrogen bond conversation with 1 fluorine atom of the trifluoromethyl of Alpelisib. Amide group and residue of Gln859 and Val851 carried out a pair of donor–acceptor hydrogen bonds.On top of that, immunofluorescence labeling of cell proliferation marker Ki67 confirmed a major minimize in proliferating Ki67 cells in tum